Pub-Med Articles

Ga-NOTA-CHSg and 99mTc-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning

Ga-NOTA-CHSg and 99mTc-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning

Fast biodegradable (12 h < half-life < 48 h) radioactive labeled microspheres are needed for PET and SPECT lung perfusion and radiomicrosphere therapy planning.

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18F-FLT Positron Emission Tomography/Computed Tomography Imaging in Pancreatic Cancer

18F-FLT Positron Emission Tomography/Computed Tomography Imaging in Pancreatic Cancer

Determination of Tumor Proliferative Activity and Comparison with Glycolytic Activity as Measured by 18F-FDG Positron Emission Tomography/Computed Tomography Imaging.

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Liver Resection for Metastatic Disease After Y90 Radioembolization: A Case Series with Long-Term Follow-Up

Liver Resection for Metastatic Disease After Y90 Radioembolization: A Case Series with Long-Term Follow-Up

There are only few reports of liver resectionsfor metastatic disease in patients previously treated with Y-90 radioembolization (RE), and long-term outcome data are sparse. We reviewed our center’s experience.

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Hepatic Structural Dosimetry in 90Y Microsphere Treatment

Hepatic Structural Dosimetry in 90Y Microsphere Treatment

A Monte Carlo Modeling Approach Based on Lobular Microanatomy. Selective internal radiation treatment (SIRT) via intrahepatic arterial administration of 90Y microspheres is emerging as a mainstream therapeutic modality.

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Posttherapy Radiation Safety Considerations in Radiomicrosphere Treatment with 90Y-Microspheres

Posttherapy Radiation Safety Considerations in Radiomicrosphere Treatment with 90Y-Microspheres

Radiomicrosphere treatment involves the intrahepatic arterial administration of 90Y-resin or 90Y-glass microspheres. The microspheres are biocompatible, but not biodegradable, and little to no 90Y leaches from the microspheres.

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PET/CT in Patients with Differentiated Thyroid Cancer: Clinical and Quantitative Image Analysis

PET/CT in Patients with Differentiated Thyroid Cancer: Clinical and Quantitative Image Analysis

The objectives of this study were to determine the imaging characteristics and clinical feasibility of 124I positron emission tomography/computed tomography (PET/CT) for the determination of extent of disease and evaluation of RAI kinetics in its physiologic and neoplastic distribution in patients with differentiated thyroid cancer (DTC).

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The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases

The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases

The objectives of this study were to investigate the relationship between functional tumor parameters (FTV and TLG) and clinical outcomes in patients with colorectal cancer liver metastases (CRCLM) undergoing 90Y-resin microsphere selective internal radiation therapy (SIRT) (SIR-Spheres®, Sirtex Medical Limited, Lane Cove, NSW, Australia).

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Yttrium-90 Microsphere-selective Internal Radiation Therapy With Chemotherapy (Chemo-SIRT) for Colorectal Cancer Liver Metastases

Yttrium-90 Microsphere-selective Internal Radiation Therapy With Chemotherapy (Chemo-SIRT) for Colorectal Cancer Liver Metastases

The aim of this study was to investigate the objective responses obtained by 90Y microsphere treatment when combined with contemporary chemotherapy in the front-line setting in patients with CRCLM.

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Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy

Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy

In a combined analysis of data from 2 randomized studies, the addition of selective internal radiation therapy to first-line chemotherapy in patients with mCRC was associated with statistically and clinically significant overall survival gains for patients with a right-sided primary tumor.

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Chemotherapy with Yttrium 90 Microsphere Selective Internal Radiation Treatment and Selective External Radiation Treatment in Patients with Metastatic Pancreatic Cancer

Chemotherapy with Yttrium 90 Microsphere Selective Internal Radiation Treatment and Selective External Radiation Treatment in Patients with Metastatic Pancreatic Cancer

Pancreatic cancer remains a disease with a poor prognosis. Historically, response rates to chemotherapy alone remain low, and response duration last only months, with no clear improvement in survival. This study compiled the data from a pilot phase II trial and retrospective review of cases.

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Measurement of Functional Tumor Volume for Fluorodeoxyglucose-Positive Primary and Metastatic Liver Tumors: Validation of Optimal Threshold Value Technique

Measurement of Functional Tumor Volume for Fluorodeoxyglucose-Positive Primary and Metastatic Liver Tumors: Validation of Optimal Threshold Value Technique

A more comprehensive approach involving the determination of functional tumor volume is needed to better define disease biology and express treatment-related changes.

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Technical Issues in Radioembolization with Yttrium 90 Microspheres

Technical Issues in Radioembolization with Yttrium 90 Microspheres

Radioembolization with radioactive microspheres is now an accepted therapeutic option for patients with liver malignancies. Knowledge of hepatic arterial anatomy is critical to safely administer this therapy.

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Dosimetric Techniques in 90Y-Microsphere Therapy of Liver Cancer: The MIRD Equations for Dose Calculations

Dosimetric Techniques in 90Y-Microsphere Therapy of Liver Cancer: The MIRD Equations for Dose Calculations

Therapy with 90Y-microspheres is emerging as a mainstream treatment modality in the management of patients with primary and metastatic liver cancer.

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Considerations in Y-90 Microsphere Administration Via Hepatic Arterial Pump

Considerations in Y-90 Microsphere Administration Via Hepatic Arterial Pump

The clinical and technical factors involved in Y-90 resin microsphere administration via a hepatic arterial infusion pump were reviewed. The pump route is safe and feasible when an appropriate technique is used.

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Radiomicrosphere Therapy: Nuclear Medicine Considerations, Guidelines, and Protocols

Radiomicrosphere Therapy: Nuclear Medicine Considerations, Guidelines, and Protocols

The clinical application of radiomicrosphere therapy using yttrium 90 microspheres is steadily expanding. Nuclear medicine has a paramount role in the refinement of the technology involved in Y RMT.

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